Powers is an odd comic. In a world filled with parodies of classic DC and Marvel super heroes, Powers is just about a pair of homicide detectives that have to deal with it, and do their jobs. Specifically, they're the officers that get assigned all of the Powers related homicide cases. In a world full of people that are bullet proof, can walk through walls, or kill with their thoughts, these two try and figure out who did the killing, and then go out with nothing more than their sidearms in order to make an arrest.
It's a fairly ridiculous concept really, on their side, the police simply have "drainers" installed in all of their cells and interrogation rooms, which are able to dampen the abilities of powers. Out in the field though, there's nothing these guys can do to half the people they're fighting, they're reliant on superheroes to take down any supervillains that are resisting arrest. Really, actually bringing the perpetrators is rarely the focus of the stories, it's very much written as a mystery, with them trying to establish motive and means, with a side of the traditional cop politics viewed through the slight skew of a world for supermen.
Final word is that I think that's a well written character driven story, with a nice cartoony look to it, that somehow all works.